Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

E. Allen Sickmier, Katherine Frato, Haihong Shen, +3

Molecular Cell

Systems BiologyNatural SciencesMolecular BiologyStructural BasisPolypyrimidine Tract Recognition +6

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

Randy Hecht, Yuesheng Li, Jeonghoon Sun, +18

PLoS ONE

Human GrowthPeptide ScienceBiomedical EngineeringNative Fgf21Rationale-based Engineering +22

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Yuan Cheng, Ted Judd, Michael D. Bartberger, +19

Journal of Medicinal Chemistry

Structural Basis for Apelin Control of the Human Apelin Receptor

Yingli Ma, Yang Yue, Yanbin Ma, +17

Structure

Molecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicineReceptor Tyrosine Kinase +7

X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing

E. Allen Sickmier, Dimitris Brekasis, Shanthi R. Paranawithana, +4

Structure

X-ray CrystallographyRedox SignalingBiochemistryRedox RegulatorX-ray Structure +7

Fragment-Linking Approach Using ¹⁹ F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

John B. Jordan, Douglas A. Whittington, Michael D. Bartberger, +4

Journal of Medicinal Chemistry

The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

E. Allen Sickmier, Robert J. Kurzeja, Klaus Michelsen, +3

PLoS ONE

ImmunologyPathologySingle Point MutationCancer BiologySignaling Pathway +15

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

John G. Allen, Mirna Mujacic, Michael Frohn, +18

ACS Chemical Biology

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Matthew M. Weiss, Toni Williamson, Safura Babu‐Khan, +35

Journal of Medicinal Chemistry

Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

Jing Xu, Jeanine L. Bussiere, Junming Yie, +5

Bioconjugate Chemistry

Sustained PotencyEngineeringGlycobiologyBiomedical EngineeringType Ii +16