Hauke Winkelmann

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio et al. · Science · 2020 · 181 citations · Full text

Receptor Dimers, Immunology, Molecular Biology +18

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Silvia Gaggero, Jonathan Martínez‐Fábregas, Adeline Cozzani et al. · Science Immunology · 2022 · 74 citations · Full text

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Ignacio Moraga, David Richter, Stephan Wilmes et al. · Science Signaling · 2015 · 68 citations · Full text

Immune Regulation, Immunology, Immunologic Mechanism +18

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Caleb R. Glassman, Leon Su, Sonia Majri-Morrison et al. · eLife · 2021 · 38 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +21

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

David Richter, Ignacio Moraga, Hauke Winkelmann et al. · Nature Communications · 2017 · 37 citations · Full text