Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota

Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, +20

Nature

High-throughput identification of antigen-specific TCRs by TCR gene capture

Carsten Linnemann, Bianca Heemskerk, Pia Kvistborg, +25

Nature Medicine

MedicineImmunologyTcr Gene CaptureAutoimmunityNucleic Acid Amplification +4

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice

Anna Staffas, Marina Burgos da Silva, Ann E. Slingerland, +20

Cell Host & Microbe

NutritionProbioticDysbiosisIntestinal TransplantationHematology +10

Naturally Processed Non-canonical HLA-A*02:01 Presented Peptides

E Chabrol, Lorenz Jahn, Michel G.D. Kester, +7

Journal of Biological Chemistry

Age-related epithelial defects limit thymic function and regeneration

Anastasia I. Kousa, Lorenz Jahn, Kelin Zhao, +35

Nature Immunology

TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1

Lorenz Jahn, Pleun Hombrink, Renate S. Hagedoorn, +11

Blood

Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b

Lorenz Jahn, Pleun Hombrink, Michel G.D. Kester, +5

Blood

Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies

Lorenz Jahn, Dirk M. van der Steen, Renate S. Hagedoorn, +7

Oncotarget

ImmunologyCd20-targeting Monoclonal AntibodiesImmunodominanceAntigen ProcessingImmunotherapy +15

Identification of Biological Relevant Minor Histocompatibility Antigens within the B-lymphocyte–Derived HLA-Ligandome Using a Reverse Immunology Approach

Pleun Hombrink, Michel G.D. Kester, Lorenz Jahn, +7

Clinical Cancer Research

A broad and systematic approach to identify B cell malignancy-targeting TCRs for multi-antigen-based T cell therapy

Miranda H. Meeuwsen, Anne K. Wouters, Lorenz Jahn, +11

Molecular Therapy