IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

Alana G. Lerner, John-Paul Upton, Paurush Praveen, +14

Cell Metabolism

InflammationIrremediable Er StressSignal TransductionThioredoxin-interacting ProteinSignaling Pathway +9

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Christine M. Oslowski, Takashi Hara, Bryan O’Sullivan-Murphy, +11

Cell Metabolism

InflammationSignal TransductionMedicineApoptosisImmunology +8

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

Brian W. Parks, Elizabeth Nam, Elin Org, +20

Cell Metabolism

ObesityNutritionMetabolic SyndromeDysbiosisBody Composition +13

Genetic Architecture of Insulin Resistance in the Mouse

Brian W. Parks, Tamer Sallam, Margarete Mehrabian, +18

Cell Metabolism

Insulin ResistanceMetabolic SyndromeKnockout MouseGeneticsDiabetes +4

Thioredoxin‐interacting protein deficiency induces Akt/Bcl‐xL signaling and pancreatic beta‐cell mass and protects against diabetes

Junqin Chen, Simon T. Hui, Francesca M. Couto, +6

The FASEB Journal

Pancreatic Beta-cell LossImmunologyCell DeathMetabolic RemodelingInsulin Signaling +14

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

Simon T. Hui, Allen M. Andres, Amber K. Miller, +8

Proceedings of the National Academy of Sciences

Metabolic RemodelingRedox BiologyOxidative StressMetabolic SyndromeSignaling Pathway +18

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

Karthickeyan Chella Krishnan, Zeyneb Kurt, Rio Barrere‐Cain, +17

Cell Systems

Metabolic SyndromeHepatologyMitochondrial FunctionMitochondrial BiogenesisLiver Physiology +12

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

Frode Norheim, Yehudit Hasin-Brumshtein, Laurent Vergnes, +13

Cell Metabolism

Metabolic SyndromeMitochondrial FunctionMitochondrial DynamicGeneticsPhysiology +4

The genetic architecture of NAFLD among inbred strains of mice

Simon T. Hui, Brian W. Parks, Elin Org, +12

eLife

GeneticsGenetic EpidemiologyLiver SteatosisMolecular GeneticsFatty Liver Disease +22

Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes

Paola León‐Mimila, Hugo Villamil‐Ramírez, X.S. Li, +20

Diabetes & Metabolism

ObesityMetabolic SyndromeTrimethylamine N-oxide LevelsMetabolic DisorderObese Subjects +7