Trevor Howe

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 836 citations · Full text

MetaSite:  Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Gabriele Cruciani, Emanuele Carosati, Benoît De Boeck et al. · Journal of Medicinal Chemistry · 2005 · 475 citations

Metabolomic Profiling, Human Cytochrome P450, Metabolic Model +20

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 392 citations

Pharmacological Characterization, Active Group 2, Psychotropic Medication +16

Dimerization of G-Protein-Coupled Receptors

Mark K. Dean, Christopher Higgs, Richard E. Smith et al. · Journal of Medicinal Chemistry · 2001 · 137 citations

Receptor Dimer, Signal Transduction, Molecular Physiology +15

Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen

Robert M. Adlington, Jack E. Baldwin, Beining Chen et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 77 citations

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +10