A Mitosis Block Links Active Cell Cycle with Human Epidermal Differentiation and Results in Endoreplication

Jennifer Zanet, Ana Freije, María Ruiz‐Soto, +4

PLoS ONE

Human Epidermal DifferentiationChromatinSkin DevelopmentCell LineageDevelopmental Biology +12

Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage

Ana Freije, Rut Molinuevo, Laura Ceballos, +7

Cell Reports

Cyclin E drives human keratinocyte growth into differentiation

Ana Freije, Laura Ceballos, Marjorie Coisy, +5

Oncogene

Skin DevelopmentCell DivisionCell ProliferationMedicineCell Biology +2

Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint

Isabel de Pedro, Pilar Alonso‐Lecue, Natalia Sanz‐Gómez, +2

Cell Death and Disease

FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53

Rut Molinuevo, Ana Freije, Isabel de Pedro, +3

Oncogene

Keratinocyte Differentiation by Flow Cytometry

Natalia Sanz‐Gómez, Ana Freije, Alberto Gandarillas

Methods in molecular biology

Skin DevelopmentCell DivisionCutaneous BiologyHistopathologyCytometry +5

The DNA damage response links human squamous proliferation with differentiation

Rut Molinuevo, Ana Freije, Lizbeth Contreras, +2

The Journal of Cell Biology

Dna DamageGeneticsGenomic MechanismDdr PathwaysEpigenetics +17

Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells

Pilar Alonso‐Lecue, Isabel de Pedro, Vincent Coulon, +14

Cell Death and Disease

Response of head and neck epithelial cells to a DNA damage‐differentiation checkpoint involving polyploidization

Natalia Sanz‐Gómez, Ana Freije, Laura Ceballos, +5

Head & Neck

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Lucía San Juan, Ana Freije, Natalia Sanz‐Gómez, +7

Cell Death Discovery