Diane N. Singhroy

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

Peter K. Quashie, Thibault Mésplède, Ying-Shan Han et al. · Journal of Virology · 2011 · 235 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

Thibault Mésplède, Peter K. Quashie, Nathan Osman et al. · Retrovirology · 2013 · 132 citations · Full text

Life Sciences, Infectious Diseases, Pharmacotherapy +17

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

Diane N. Singhroy, Thibault Mésplède, Arielle Sabbah et al. · Retrovirology · 2013 · 61 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity

Thibault Mésplède, Nathan Osman, Melissa Wares et al. · Journal of Antimicrobial Chemotherapy · 2014 · 50 citations · Full text

Life Sciences, Infectious Diseases, Pharmacotherapy +17

Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers

Diane N. Singhroy, Emily MacLean, Mikashmi Kohli et al. · Gates Open Research · 2020 · 47 citations · Full text

Public Health, Infectious Disease Control, Preventive Medicine +15