A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

Yunan Luo, Xinbin Zhao, Jingtian Zhou, +6

Nature Communications

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Li Che, Wenna Chi, Yu Qiao, +23

Gut

SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility

Wenhua Kuang, Jie Zhang, Lan Zhou, +18

Cell Reports

A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information

Yunan Luo, Xinbin Zhao, Jingtian Zhou, +6

New DtiDrug TargetEngineeringInteraction NetworkNetwork Analysis +20

Downregulation of miR-27a* and miR-532-5p and Upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 Macrophage Cells

Ying Cheng, Wenhua Kuang, Yongchang Hao, +6

Inflammation

InflammationImmune Cell DevelopmentMedicineNatural SciencesImmunology +7

Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway

Guanjun Li, Xueyan Liu, Xin Sun, +12

Environment International

Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity

Lili Cheng, Meng-Meng Ge, Zhou Lan, +21

Archives of Toxicology

Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system

Fengzhi Zhang, Yonglin Zhu, Jing Chen, +13

Biomaterials

Induced Pluripotent Stem CellDevelopmental BiologyMedicineStem Cell ResearchStem-cell Therapy +5

A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Xuanxiu Ren, Jiawen Sun, Wenhua Kuang, +11

Nature Communications

Synthesis, characterization, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new functionalized terpyridine platinum(II) complexes

Keke Chai, Wenhua Kuang, Lan Zhou, +6

Journal of Inorganic Biochemistry

Inorganic ChemistryMedicinal ChemistryDna BindingBiochemistryTerpyridine Platinum +9