Li Che

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Li Che, Wenna Chi, Yu Qiao et al. · Gut · 2019 · 197 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis

Liu Pin, Meng-Meng Ge, Junjie Hu et al. · Hepatology · 2017 · 196 citations · Full text

Medicine, Molecular Biology, Oncology +17

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Shanshan Zhang, Xinhua Song, Dan Cao et al. · Journal of Hepatology · 2017 · 185 citations · Full text

Medicine, Oncology, Pharmacology +16

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

Lei Li, Giulia M. Pilo, Xiaolei Li et al. · Journal of Hepatology · 2015 · 151 citations

Life Sciences, Molecular Biology, Oncology +11

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

Junjie Hu, Li Che, Lei Li et al. · Scientific Reports · 2016 · 125 citations · Full text

Medicine, Cell Biology, Oncology +17