Shiho Shimabukuro-Demoto

The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production

Toshihiko Kobayashi, Shiho Shimabukuro-Demoto, Reiko Yoshida-Sugitani et al. · Immunity · 2014 · 157 citations · Full text

Inflammation, Molecular Immunology, Autoimmune Disease +9

Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity

Toshihiko Kobayashi, Dat Nguyen-Tien, Daisuke Ohshima et al. · International Immunology · 2021 · 49 citations

Inflammation, Autoimmune Disease, Human Slc15a4 +15

SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress

Toshihiko Kobayashi, Dat Nguyen-Tien, Yuriko Sorimachi et al. · Proceedings of the National Academy of Sciences · 2021 · 48 citations · Full text

Microbial Pathogens, Immunology, Immune Regulation +28

Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells

Toshihiko Kobayashi, Hidemitsu Tsutsui, Shiho Shimabukuro-Demoto et al. · International Immunology · 2017 · 36 citations · Full text

Mtorc1-tfeb Signaling Axis, Mast Cell Disorder, Immunology +25

Type I interferon limits mast cell–mediated anaphylaxis by controlling secretory granule homeostasis

Toshihiko Kobayashi, Shiho Shimabukuro-Demoto, Hidemitsu Tsutsui et al. · PLoS Biology · 2019 · 18 citations · Full text

Clinical Immunology, Inflammatory Lung Disease, Mast Cell Disorder +24