The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, +11

Immunity

InflammationAutoimmune DiseaseThymic Medullary MicroenvironmentCd40 Cooperatively EstablishImmunology +9

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, +20

Nature Communications

Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, +12

The Journal of Experimental Medicine

Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity

Toshihiko Kobayashi, Dat Nguyen-Tien, Daisuke Ohshima, +4

International Immunology

InflammationAutoimmune DiseaseHuman Slc15a4Mtorc1 ActivityInnate Immune System +13

TRAF6 directs commitment to regulatory T cells in thymocytes

Yusuke Shimo, Hiromi Yanai, Daisuke Ohshima, +6

Genes to Cells

Lymphocyte DevelopmentT-regulatory CellImmunologyImmune RegulationRegulatory T Cells +20

Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells

Toshihiko Kobayashi, Hidemitsu Tsutsui, Shiho Shimabukuro-Demoto, +7

International Immunology

Mtorc1-tfeb Signaling AxisMast Cell DisorderImmunologyMolecular BiologyImmunologic Mechanism +23

Lack of an Inducible Effect of Dietary Soy Isoflavones on the mRNA Abundance of Hepatic Cytochrome P-450 Isozymes in Rats

Taro Kishida, Manabu Nagamoto, Yohhei Ohtsu, +7

Bioscience Biotechnology and Biochemistry

PolyphenolicsOxidative StressTranscriptional RegulationHepatotoxicityInducible Effect +16

Developmental Stage-Dependent Collaboration between the TNF Receptor-Associated Factor 6 and Lymphotoxin Pathways for B Cell Follicle Organization in Secondary Lymphoid Organs

Junwen Qin, Hiroyasu Konno, Daisuke Ohshima, +8

The Journal of Immunology

Spatio-temporal Dynamics and Mechanisms of Stress Granule Assembly

Daisuke Ohshima, Kyoko Arimoto‐Matsuzaki, Taichiro Tomida, +2

PLoS Computational Biology

Signal TransductionDevelopmental BiologyCell InteractionStress Granule AssemblyGene Expression +13

Silicon-Photonics-Embedded Interposers as Co-Packaged Optics Platform

Koichi Takemura, Daisuke Ohshima, Akihiro Noriki, +10

Transactions of The Japan Institute of Electronics Packaging

EngineeringDevice IntegrationIntegrated CircuitsSi-photonics TransceiverProgrammable Photonics +14