Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

Sonja I. Gringhuis, Tanja M. Kaptein, Brigitte A. Wevers, +4

Nature Immunology

InflammationNoncanonical Caspase-8 InflammasomeCytokineExtracellular Pathogen SensorMicrobial Pathogens +7

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

Sonja I. Gringhuis, Brigitte A. Wevers, Tanja M. Kaptein, +5

PLoS Pathogens

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

Brigitte A. Wevers, Tanja M. Kaptein, Esther M. Zijlstra-Willems, +4

Cell Host & Microbe

Antifungal AgentFungal Cell BiologyAntifungal AgentsPathogenesisImmunology +5

Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation

Sonja I. Gringhuis, Tanja M. Kaptein, Brigitte A. Wevers, +2

Nature Communications

Cyld-dependent Bcl3 ActivationSignal TransductionAutoimmune DiseaseAdaptive Immune SystemT-regulatory Cell +10

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

Sonja I. Gringhuis, Nina Hertoghs, Tanja M. Kaptein, +10

Nature Immunology

Host Helicase Ddx3Viral ReplicationHuman RetrovirusImmunologyAntiviral Response +6

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

Sonja I. Gringhuis, Tanja M. Kaptein, Brigitte A. Wevers, +6

Nature Communications

InflammationCytokineAutoimmune DiseaseDc-sign-dependent Il-27 ProductionT-regulatory Cell +8

Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases

Annelies W. Mesman, Esther M. Zijlstra-Willems, Tanja M. Kaptein, +7

Cell Host & Microbe

Pp1 PhosphatasesViral PathogenesisImmunologyAntiviral ResponseVirology +7

Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans

Marta Bermejo‐Jambrina, Julia Eder, Tanja M. Kaptein, +12

The EMBO Journal

RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation

Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, +3

The Journal of Immunology

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, +3

PLoS Pathogens

Dengue VirusAdaptive Immune SystemInnate Immune SystemImmunologyImmune Regulation +24