Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo

Kai-Wen Cheng, Chih-Hua Tseng, Cherng‐Chyi Tzeng, +10

Pharmacological Research

Health SciencesMicrobial PathogensGastrointestinal PharmacologyMedicineGastroenterology +7

SN38-loaded <100 nm targeted liposomes for improving poor solubility and minimizing burst release and toxicity: in vitro and in vivo study

Yi‐Ping Fang, Chih-Hung Chuang, Yi‐Jhun Wu, +2

International Journal of Nanomedicine

Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

I‐Ju Chen, Chih-Hung Chuang, Yuan-Chin Hsieh, +10

Scientific Reports

Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-<i>c</i>]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity

Kai-Wen Cheng, Chih-Hua Tseng, Chia‐Ning Yang, +8

Journal of Medicinal Chemistry

Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

Yi‐An Cheng, I‐Ju Chen, Yu-Cheng Su, +8

Biomaterials Science

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

Yun‐Chi Lu, Chih-Hung Chuang, Kuo‐Hsiang Chuang, +11

PLoS Biology

ImmunologyImmune RegulationInnate ImmunityImmune SystemImmunotherapy +25

Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes

I‐Ju Chen, Yi‐An Cheng, Kai‐Wen Ho, +10

Acta Biomaterialia

Drug TargetingBispecific AntibodyHer2 × MpegImmunologyPrecise Targeting +6

Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

Yi‐An Cheng, Tung-Ho Wu, Yun‐Ming Wang, +11

Journal of Nanobiotechnology

Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice

Wen-Wei Lin, Kai‐Wen Ho, Hsiang-Han Su, +11

Frontiers in Immunology

Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules

Wen-Wei Lin, Yuan-Chin Hsieh, Yi‐An Cheng, +10

Analytical Chemistry