Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes

Yuan-Chin Hsieh, Hsin-Ell Wang, Wen-Wei Lin, +10

Theranostics

Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

I‐Ju Chen, Chih-Hung Chuang, Yuan-Chin Hsieh, +10

Scientific Reports

Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy

Chih-Hung Chuang, Pao‐Chu Wu, Teng-Huang Tsai, +10

Journal of Biomedical Nanotechnology

NanoparticlesNanotherapeuticsSelective Cancer-targeted TherapyEngineeringSpherical Nanoparticles +17

Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

Yi‐An Cheng, I‐Ju Chen, Yu-Cheng Su, +8

Biomaterials Science

Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates

Yi-Jou Chen, Michael Chen, Yuan-Chin Hsieh, +7

Scientific Reports

EngineeringImmunologyPolystyrene-based MicroplatesImmunodominanceImmunotherapeutics +19

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

Yun‐Chi Lu, Chih-Hung Chuang, Kuo‐Hsiang Chuang, +11

PLoS Biology

ImmunologyImmune RegulationInnate ImmunityImmune SystemImmunotherapy +25

Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes

I‐Ju Chen, Yi‐An Cheng, Kai‐Wen Ho, +10

Acta Biomaterialia

Drug TargetingBispecific AntibodyHer2 × MpegImmunologyPrecise Targeting +6

Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules

Wen-Wei Lin, Yuan-Chin Hsieh, Yi‐An Cheng, +10

Analytical Chemistry

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles

Yuan-Chin Hsieh, Ta-Chun Cheng, Hsin-Ell Wang, +9

Scientific Reports

Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules

Wen-Wei Lin, Yi‐An Cheng, Chien-Han Kao, +11

Analytical Chemistry