Michelle L. Heathcote

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Steven Howard, Valério Berdini, John A. Boulstridge et al. · Journal of Medicinal Chemistry · 2008 · 329 citations · Full text

Drug Target, Pyrazol-4-yl Urea, Clinical Candidate +18

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

Michelle L. Heathcote, James Staunton, Peter F. Leadlay · Chemistry & Biology · 2001 · 193 citations · Full text

Aberrant Decarboxylation, Aldehyde Dehydrogenase, Biochemistry +10

Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry

Sue Hutchinson, Melanie Leveridge, Michelle L. Heathcote et al. · SLAS DISCOVERY · 2011 · 99 citations · Full text

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Barbara M. R. Harvey, Hui Hong, Michelle Jones et al. · ChemBioChem · 2006 · 63 citations

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

John Liddle, Paul Bamborough, Michael D. Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 26 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Medicine +9