Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

Tomoya Yamada, Yu Okuda, Masahiko Kushida, +7

Toxicological Sciences

Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

Yoshihito Deguchi, Tomoya Yamada, Y Hirose, +9

Toxicological Sciences

PathologyCell DeathHepatic Cyp2b InductionTumor BiologyOxidative Stress +19

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

Y Hirose, Hirohisa Nagahori, Tomoya Yamada, +8

Toxicology

Molecular PharmacologyCyp2b Form InductionReplicative Dna SynthesisBiochemistryMedicine +5

An in Vitro Reporter Gene Assay Method Incorporating Metabolic Activation with Human and Rat S9 or Liver Microsomes

Kayo Sumida, Norihisa Ooe, Hirohisa Nagahori, +4

Biochemical and Biophysical Research Communications

Systems BiologyRat S9Reporter Gene AssayLiver PhysiologyMetabolic Regulation +9

Quantitative Structure–Activity Relationship Model for the Fetal–Maternal Blood Concentration Ratio of Chemicals in Humans

Tomoyuki Takaku, Hirohisa Nagahori, Yoshihisa Sogame, +1

Biological and Pharmaceutical Bulletin

Fetal MedicinePlacental TransferBioanalysisBiostatisticsAnalytical Chemistry +21

Metabolism of Furametpyr. 1. Identification of Metabolites and in Vitro Biotransformation in Rats and Humans

Hirohisa Nagahori, Hiromi Yoshino, Yoshitaka Tomigahara, +3

Journal of Agricultural and Food Chemistry

BiochemistryMedicinePyrazole RingMetabolomic ProfilingSecondary Metabolite +13

Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST): A novel rapid and highly reproducible <i>in vitro</i> test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells

Florian Le Coz, Noriyuki Suzuki, Hirohisa Nagahori, +2

The Journal of Toxicological Sciences

Adult Stem CellCell DifferentiationBiomedical EngineeringStem Cell BiologyEmbryology +17

Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Yu Okuda, Masahiko Kushida, Kayo Sumida, +7

Toxicological Sciences

Chemoprevention StrategyPathologyToxicological MechanismTumor BiologySynthetic Pyrethroid Momfluorothrin +14

Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals

Tomoyuki Takaku, Hirohisa Nagahori, Yoshihisa Sogame

Toxicology and Applied Pharmacology

Pharmacokinetic ModelingPharmacological StudyMedicinePhysiologyToxicology +8

Species differences in the developmental toxicity of procymidone—Placental transfer of procymidone in pregnant rats, rabbits, and monkeys—

Hirokazu Tarui, Yoshitaka Tomigahara, Hirohisa Nagahori, +5

Journal of Pesticide Science