Hitesh Bhagavanbhai Mangukiya

Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization

Hao Guo, Qi Zhu, Xiaoyan Yu et al. · Oncogene · 2017 · 111 citations

Developmental Biology, Fibroblast Growth Factor, Cell Proliferation +9

Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study

Hema Negi, Siva Bharath Merugu, Hitesh Bhagavanbhai Mangukiya et al. · Cancer Letters · 2019 · 63 citations

Oncology, Medicine, Preclinical Study +13

Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain

Qi Zhu, Hitesh Bhagavanbhai Mangukiya, Dhahiri Saidi Mashausi et al. · FEBS Journal · 2017 · 60 citations · Full text

Tissue Engineering, Anterior Gradient 2, Dermatology +16

Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains

Siva Bharath Merugu, Bingjie Zhou, Hitesh Bhagavanbhai Mangukiya et al. · Biochemical and Biophysical Research Communications · 2021 · 27 citations

Agr2 Dimerization, Signal Transduction, Medicine +14

A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth

Hao Guo, Hao Chen, Qi Zhu et al. · Biochemical and Biophysical Research Communications · 2016 · 23 citations

Tumor Biology, Anterior Gradient 2, Medicine +8