Mincle is an ITAM-coupled activating receptor that senses damaged cells

Sho Yamasaki, Eri Ishikawa, Machie Sakuma, +3

Nature Immunology

Molecular PhysiologySignal TransductionItam-coupled Activating ReceptorCell InteractionReceptor (Biochemistry) +7

Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury

Masayuki Ishihara, Madoka Urushido, Kazu Hamada, +9

American Journal of Physiology-Renal Physiology

MitophagyRenal InflammationRedox BiologyOxidative StressInflammation +19

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

Yoshiko Shimamura, Kazu Hamada, Kosuke Inoue, +10

Clinical and Experimental Nephrology

Early DiagnosisUrologyRenal DiseaseRenal FunctionMedicine +10

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

Sho Yamasaki, Eri Ishikawa, Machie Sakuma, +6

Nature Immunology

Signal TransductionDevelopmental BiologyLymphocyte DevelopmentImmune Cell DevelopmentMechanistic Basis +12

Activation of CO₂by ionic liquid EMIM–BF₄in the electrochemical system: a theoretical study

Yuanqing Wang, Makoto Hatakeyama, Koji Ogata, +3

Physical Chemistry Chemical Physics

EngineeringOrganometallic ElectrochemistryChemistryTheoretical ElectrochemistryIon Process +16

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Elisa Leung, Alessandro Datti, Michele Cossette, +14

Chemistry & Biology

Protease InhibitorsBiochemistryProtein AssemblyCylindrical ProteasesNatural Sciences +7

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Gregory D. Fairn, Koji Ogata, Roberto J. Botelho, +6

The Journal of Cell Biology

CRYBA4, a Novel Human Cataract Gene, Is Also Involved in Microphthalmia

Gail Billingsley, Sathiyavedu Thyagarajan Santhiya, Andrew D. Paterson, +8

The American Journal of Human Genetics

Ocular DiseaseOphthalmologyMedicineOcular TissueOptogenetics +2

An automatic homology modeling method consisting of database searches and simulated annealing

Koji Ogata, Hideaki Umeyama

Journal of Molecular Graphics and Modelling

Computational ScienceEngineeringData ScienceSimulated AnnealingMethod Consisting +8

Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Kosuke Inoue, Hitoshi Kuwana, Yoshiko Shimamura, +9

Clinical and Experimental Nephrology

Cell RegulationCisplatin-induced MacroautophagyApoptosisAutophagyCell Death +8