Biosynthetic Processing of Cathepsins and Lysosomal Degradation Are Abolished in Asparaginyl Endopeptidase-deficient Mice

Kanae Shirahama‐Noda, Akitsugu Yamamoto, Kazushi Sugihara, +4

Journal of Biological Chemistry

Protein SecretionMolecular BiologyCytoskeletonCellular PhysiologyOxidative Stress +21

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

Yukio Kato, Yoshiyuki Kubo, Daisuke Iwata, +15

Pharmaceutical Research

Molecular PharmacologyAldo-keto ReductaseBiochemistryMedicineGene Knockout +3

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, +21

Nature Medicine

Endothelial Cell PathobiologySignal TransductionDevelopmental BiologyAngiogenesisClass Ii Pi3k +9

S1P2, the G Protein–Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth <i>In vivo</i> in Mice

Wa Du, Noriko Takuwa, Kazuaki Yoshioka, +6

Cancer Research

Expression and distribution of JNK/SAPK‐associated scaffold protein JSAP1 in developing and adult mouse brain

Eriko Miura, Masahiro Fukaya, Tokiharu Sato, +4

Journal of Neurochemistry

Cellular NeurobiologyCellular PhysiologySocial SciencesJnk-associated ScaffoldSignaling Pathway +16

Important role of heparan sulfate in postnatal islet growth and insulin secretion

Iwao Takahashi, Naoya Noguchi, Koji Nata, +16

Biochemical and Biophysical Research Communications

Postnatal Islet GrowthImportant RoleDevelopmental BiologyGrowth HormoneBiochemistry +11

EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner

Satomi Nadanaka, Shaobo Zhou, Shoji Kagiyama, +5

Journal of Biological Chemistry

<i>PSF1</i> Is Essential for Early Embryogenesis in Mice

Masaya Ueno, Machiko Itoh, Lingyu Kong, +3

Molecular and Cellular Biology

Developmental BiologySignaling PathwayGerm CellNatural SciencesGenetics +12

Impairment of Embryonic Cell Division and Glycosaminoglycan Biosynthesis in Glucuronyltransferase-I-deficient Mice

Tomomi Izumikawa, N. Kanagawa, Yukiko Watamoto, +7

Journal of Biological Chemistry

GlycobiologyImmunologyCell CultureGlucuronyltransferase-i-deficient MiceCellular Physiology +15

Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

Toru Yoshihara, Hiroyuki Satake, Toshikazu Nishie, +12

PLoS Genetics

Lysosomal Storage DiseaseBrain DevelopmentMolecular BiologyCellular NeurobiologyCellular Physiology +25