Éric Therrien

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Wei Jia, Silvana Leit, Jun Kuai et al. · Nature · 2019 · 183 citations

Biosynthesis, Biochemistry, Allosteric Mechanism +3

Synthesis of functionally diverse bicyclic sulfonamides as constrained proline analogues and application to the design of potential thrombin inhibitors

Stephen Hanessian, H. Sailes, Éric Therrien · Tetrahedron · 2003 · 98 citations

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +10

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

Martin Allan, Sukhdev Manku, Éric Therrien et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 87 citations · Full text

Biochemistry, Medicine, Mechanism Of Action +5

Medicinal Chemistry Projects Requiring Imaginative Structure-Based Drug Design Methods

Nicolas Moitessier, Joshua Pottel, Éric Therrien et al. · Accounts of Chemical Research · 2016 · 76 citations

Drug Target, Chemical Biology, Cytochrome P450 Enzymes +18

Structure-Based Design, Synthesis, and Memapsin 2 (BACE) Inhibitory Activity of Carbocyclic and Heterocyclic Peptidomimetics

Stephen Hanessian, Hongying Yun, Yihua Hou et al. · Journal of Medicinal Chemistry · 2005 · 72 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +13