Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice

Naomoto Harada, Zenjun Oda, Yoshikazu Hara, +9

Molecular and Cellular Biology

Mitochondrial Acc2CholangiopathiesLoxp SequencesHepatotoxicityMetabolic Signaling +17

Acyl-CoA:Cholesterol Acyltransferase Inhibition Reduces Atherosclerosis in Apolipoprotein E–Deficient Mice

Jun Kusunoki, Dipal K. Hansoty, Katsumi Aragane, +3

Circulation

Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation

Hiroshi Kuriyama, Shizuya Yamashita, Iichiro Shimomura, +13

Hepatology

Hepatic Acyl-coenzymeFatty Liver DiseaseVisceral Fat AccumulationObesityMetabolic Syndrome +16

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion

Mayumi Okawa, Kenji Fujii, Katsuya Ohbuchi, +7

Biochemical and Biophysical Research Communications

Metabolic SyndromeBiochemistryMedicineFood DigestionDiabetes +11

Postprandial Hyperlipidemia in Streptozotocin-Induced Diabetic Rats Is Due to Abnormal Increase in Intestinal Acyl Coenzyme A:Cholesterol Acyltransferase Activity

Jun Kusunoki, Katsumi Aragane, Tetsuya Kitamine, +6

Arteriosclerosis Thrombosis and Vascular Biology

Ph ModelMetabolic SyndromeNutritionGastrointestinal Peptide HormoneHealth Sciences +13

Synthesis and Evaluation of a Novel Indoledione Class of Long Chain Fatty Acid Elongase 6 (ELOVL6) Inhibitors

Toshiyuki Takahashi, Tsuyoshi Nagase, Takahide Sasaki, +9

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryNovel Indoledione DerivativesNovel Indoledione ClassPlasma Exposure +11

Direct effect of an acyl‐CoA:cholesterol acyltransferase inhibitor, F‐1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice

Tsuyoshi Chiwata, Katsumi Aragane, Koji Fujinami, +4

British Journal of Pharmacology

Discovery of Novel Benzoxazinones as Potent and Orally Active Long Chain Fatty Acid Elongase 6 Inhibitors

Takashi Mizutani, Shiho Ishikawa, Tsuyoshi Nagase, +12

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryTarget Fatty AcidsMedicineNovel Benzoxazinones +10

Studies on Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitory Effects and Enzyme Selectivity of F-1394, a Pantotheic Acid Derivative

Jun Kusunoki, Katsumi Aragane, Tetsuaki Yamaura, +1

The Japanese Journal of Pharmacology

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6

Ken Shimamura, Akira Nagumo, Yasuhisa Miyamoto, +10

European Journal of Pharmacology

Medicinal ChemistryActive InhibitorMedicineImmunologyMammalian Elovl6 +7