Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

Wen Cai Zhang, Ng Shyh‐Chang, Yang He, +26

Cell

Glycine Decarboxylase ActivityOncogenic AgentMedicineTumor SuppressorRadiation Oncology +5

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

Jinqiu Zhang, Wai Leong Tam, Guo Qing Tong, +11

Nature Cell Biology

Transcriptional RegulationInduced Pluripotent Stem CellDevelopmental BiologyEarly Embryonic DevelopmentMedicine +6

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

Na‐Yu Chia, Yun-Shen Chan, Bo Feng, +16

Nature

Lineage PlasticityCell LineageDevelopmental BiologyFunctional GenomicsMedicine +7

The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis

Shi‐Yan Ng, Gireesh K. Bogu, Boon-Seng Soh, +1

Molecular Cell

Transcriptional RegulationDevelopmental BiologyRna BiologyLong Non-coding RnaGene Expression +4

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

Wai Leong Tam, Haihui Lu, Joyce Y. Buikhuisen, +12

Cancer Cell

Breast OncologySignal TransductionSignaling PathwayCell RegulationMedicine +9

Tbx3 improves the germ-line competency of induced pluripotent stem cells

Jianyong Han, Ping Yuan, Henry Yang, +11

Nature

Lineage PlasticityInduced Pluripotent Stem CellDevelopmental BiologyMedicineGerm-line Competency +4

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

Shi‐Yan Ng, Boon-Seng Soh, Natalia Rodríguez‐Muela, +4

Cell stem cell

Genome-wide Rna-seqGeneticsRna BiologySpinal Muscular AtrophyNeuroscience +3

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Yi Yang, Han Wu, Xiangjin Kang, +22

Protein & Cell

GeneticsMolecular BiologyMolecular GeneticsMitochondrial BiogenesisMitochondrial Therapy +15

Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

Jin Hui Hor, Eunice Shi-Yi Soh, Li Yi Tan, +7

Cell Death and Disease

ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation

Jin‐Hui Hor, Munirah Mohamad Santosa, Valerie Jing Wen Lim, +8

Cell Death and Differentiation