Jan Chu

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

Sara Ghorashian, Anne Marijn Kramer, Shimobi Onuoha et al. · Nature Medicine · 2019 · 644 citations · Full text

Life Sciences, Immunology, Pediatrics +16

Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia

Robert Chiesa, Christos Georgiadis, Farhatullah Syed et al. · New England Journal of Medicine · 2023 · 316 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

Shaun Cordoba, Shimobi Onuoha, Simon Thomas et al. · Nature Medicine · 2021 · 272 citations · Full text

Medicine, Hematology, Oncology +17

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia

Giorgio Ottaviano, Christos Georgiadis, Soragia Athina Gkazi et al. · Science Translational Medicine · 2022 · 184 citations · Full text

Life Sciences, Biotechnology, Immunology +17

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL

Sara Ghorashian, Giovanna Lucchini, Kyvi Nguyen et al. · Blood · 2023 · 75 citations · Full text

Life Sciences, Hematology, Immunology +17