Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

Christoph Spiess, Mark Merchant, Arthur Huang, +8

Nature Biotechnology

Distinct Half-antibodiesImmunologyBacteriologySynthetic BiologyNatural Architecture +8

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

Whitney Shatz-Binder, Shan Chung, Bing Li, +6

mAbs

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab

Whitney Shatz-Binder, Philip E. Hass, Mary Mathieu, +12

Molecular Pharmaceutics

Immunocytochemical TechniqueEngineeringImmunologyPathologyPeptide Science +21

Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

Christoph Spiess, Jack Bevers, Janet Jackman, +21

Journal of Biological Chemistry

Autoimmune DiseaseAllergyHuman Bispecific AntibodiesBispecific AntibodyImmunodeficiencies +13

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics

Kapil Gadkar, Cinthia V. Pastuskovas, Jennifer E. Le Couter, +13

Investigative Ophthalmology & Visual Science

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

Susan Crowell, Kathryn Wang, Amin Famili, +7

Translational Vision Science & Technology

Separation of Plasmid DNA Topological Forms, Messenger RNA, and Lipid Nanoparticle Aggregates Using an Ultrawide Pore Size Exclusion Chromatography Column

Alexandre Goyon, Shijia Tang, Szabolcs Fekete, +8

Analytical Chemistry

Lipid NanoparticlesDna AnalysisMolecular BiologyMessenger RnaNucleic Acid Biomarkers +15

An efficient route to bispecific antibody production using single-reactor mammalian co-culture

Whitney Shatz-Binder, Domingos Ng, George Dutina, +5

mAbs

EngineeringBiological TherapySingle-reactor Mammalian Co-cultureImmunotherapySynthetic Immunology +14

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Whitney Shatz-Binder, Philip E. Hass, Nikhil Peer, +12

PLoS ONE

Ocular DiseaseEngineeringImmunologyBiomedical EngineeringTherapeutics +14

Impact of polymer geometry on the interactions of protein-PEG conjugates

Jonathan Zarzar, Whitney Shatz-Binder, Nikhil Peer, +5

Biophysical Chemistry

Cross-linkProtein FoldingMedicinePolymer ScienceNatural Sciences +7