The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

R Chin, Xudong Fu, Melody Y. Pai, +33

Nature

Lifespan ExtensionMetabolite α-Ketoglutarate ExtendsEnergy MetabolismMetabolic PathwaysBiochemistry +11

Targeted degradation of the enhancer lysine acetyltransferases CBP and p300

Raghu Vannam, Jan Fehmi Sayılgan, Samuel Ojeda, +9

Cell chemical biology

Molecular PharmacologyTranscriptional RegulationBiochemistryMedicineBiochemical Genetics +5

PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression

Shuai Dong, Bonnie K. Harrington, Eileen Hu, +9

Journal of Clinical Investigation

PERSIST platform provides programmable RNA regulation using CRISPR endoRNases

Breanna DiAndreth, Noreen Wauford, Eileen Hu, +2

Nature Communications

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, +26

Blood

Targetable DriverHematological MalignancyC-myc/p21 AxisCell SignalingAcute Myeloid Leukemia +13

The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia

Eileen Hu, Priscilla Do, Swagata Goswami, +18

Blood Advances

CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq

Logan A. Walker, Michael G. Sovic, Chi‐Ling Chiang, +8

Journal of Translational Medicine

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia

Andrew Stiff, Maarten Fornerod, Bailee Kain, +61

Nature Genetics

A functional genomics screen identifying blood cell development genes in<i>Drosophila</i>by undergraduates participating in a course-based research experience

Cory J. Evans, John M. Olson, Bama Charan Mondal, +348

G3 Genes Genomes Genetics

Metabolic versatility in a modern lineage of cyanobacteria from terrestrial hot springs

Lily Momper, Eileen Hu, Kelsey R. Moore, +4

Free Radical Biology and Medicine

BiologyBiogeochemistryEngineeringBioenergeticsTerrestrial Hot Springs +12