Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

William J. Thompson, Gary A. Piazza, Han Li, +6

PubMed

ApoptosisCell DeathTumor BiologySignaling PathwayAnti-cancer Agent +15

Possible proton relay pathways in cytochrome c oxidase.

John Fetter, Jing Qian, James P. Shapleigh, +7

Proceedings of the National Academy of Sciences

Redox SignalingRespiratory ChainCellular EnzymologyBiochemistryBioenergetics +11

Cytochrome aa3 of Rhodobacter sphaeroides as a model for mitochondrial cytochrome c oxidase. Purification, kinetics, proton pumping, and spectral analysis.

Jonathan P. Hosler, John Fetter, Mary M Tecklenburg, +3

Journal of Biological Chemistry

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.

Gary A. Piazza, William J. Thompson, Rifat Pamukcu, +9

PubMed

Urological ResearchUrologyCyclic Amp LevelsChemoprevention StrategyGenitourinary Cancer +13

Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.

Clark M. Whitehead, Keith A. Earle, John Fetter, +10

PubMed

Cgmp PdesApoptosisImmunologyPathologyCell Death +15

Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve β-catenin and cyclin D1 down-regulation

Li Han, Li Liu, Mary David, +6

Biochemical Pharmacology

Tumor BiologySignaling PathwayMedicineCell DeathPathology +9

Derivatization of peptides to enhance ionization effiency and control fragmentation during analysis by fast atom bombardment tandem mass spectrometry

David S. Wagner, Amid Salari, Douglas A. Gage, +4

Journal of Mass Spectrometry

The influence of conserved tyrosine 30 and tissue-dependent differences in sequence on ferritin function: use of blue and purple Fe(III) species as reporters of ferroxidation

John Fetter, Jonathan Cohen, Dana P. Danger, +2

JBIC Journal of Biological Inorganic Chemistry

Purple FeBiochemistryIron MetabolismMedicineNatural Sciences +8

Fatty acids stimulate activity and restore respiratory control in a proton channel mutant of cytochrome <i>c</i> oxidase

John Fetter, Martyn A. Sharpe, Jie Qian, +3

FEBS Letters

Site-Directed Mutagenesis of Residues Lining a Putative Proton Transfer Pathway in Cytochrome <i>c</i> Oxidase from <i>Rhodobacter sphaeroides</i>

David M. Mitchell, John Fetter, Denise A. Mills, +10

Biochemistry