Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

Luigi Leanza, Matteo Romio, Katrin Anne Becker, +23

Cancer Cell

Tumor BiologyMitochondrial FunctionMedicineIon ChannelsCellular Pharmacology +5

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak‐independent death of cancer cells

Luigi Leanza, Brian Henry, Nicola Sassi, +4

EMBO Molecular Medicine

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, +17

Cell Reports

Reductive StressEr Stress InductionSignal TransductionMitochondrial FunctionMitochondrial Dynamic +12

Early effects of the antineoplastic agent salinomycin on mitochondrial function

Antonella Managò, Luigi Leanza, Luca Carraretto, +11

Cell Death and Disease

Healthy SubjectsChemoprevention StrategyIonophore ValinomycinAntibiotic AdjuvantPathology +16

Correlation between Potassium Channel Expression and Sensitivity to Drug-induced Cell Death in Tumor Cell Lines

Luigi Leanza, Paul G. O’Reilly, Anne Doyle, +4

Current Pharmaceutical Design

ApoptosisCell DeathPotassium Channel ExpressionCellular PhysiologyTumor Biology +17

Thylakoid potassium channel is required for efficient photosynthesis in cyanobacteria

Vanessa Checchetto, Anna Segalla, Guillaume Allorent, +7

Proceedings of the National Academy of Sciences

Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis

Ildikò Szabó, Matthias Soddemann, Luigi Leanza, +2

Cell Death and Differentiation

Developmental BiologySignaling PathwaySingle-point MutationsBax-induced ApoptosisApoptosis +6

Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels

Luigi Leanza, Mario Zoratti, Erich Gulbins, +1

Current Medicinal Chemistry

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

Angela Zaccagnino, Antonella Managò, Luigi Leanza, +10

Oncotarget

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells

Elisa Venturini, Luigi Leanza, Michele Azzolini, +10

Neurosignals