Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

Luigi Leanza, Matteo Romio, Katrin Anne Becker, +23

Cancer Cell

Tumor BiologyMitochondrial FunctionMedicineIon ChannelsCellular Pharmacology +5

<i>Pseudomonas aeruginosa</i> Pyocyanin Induces Neutrophil Death <i>via</i> Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase

Antonella Managò, Katrin Anne Becker, Alexander Carpinteiro, +7

Antioxidants and Redox Signaling

Early effects of the antineoplastic agent salinomycin on mitochondrial function

Antonella Managò, Luigi Leanza, Luca Carraretto, +11

Cell Death and Disease

Healthy SubjectsChemoprevention StrategyIonophore ValinomycinAntibiotic AdjuvantPathology +16

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

Valentina Audrito, Antonella Managò, Sofia La Vecchia, +13

JNCI Journal of the National Cancer Institute

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Antonella Managò, Valentina Audrito, Francesca Mazzola, +14

Nature Communications

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

Angela Zaccagnino, Antonella Managò, Luigi Leanza, +10

Oncotarget

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

Roberta Peruzzo, Andrea Mattarei, Michele Azzolini, +20

Redox Biology

Molecular Mechanisms by Which a Fucus vesiculosus Extract Mediates Cell Cycle Inhibition and Cell Death in Pancreatic Cancer Cells

Ulf Geisen, Marion Zenthoefer, Matthias Peipp, +10

Marine Drugs

ImmunologyCell DeathCell CyclePancreatic Cancer CellsCell Autophagy +16

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma

Valentina Audrito, Antonella Managò, Federica Zamporlini, +10

Oncotarget

Novel MarkerImmunologyPathologyCancer BiologyTumor Biology +16

Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents

Andrea Mattarei, Matteo Romio, Antonella Managò, +5

Frontiers in Oncology