Nicholas McHugh

Statistics

Publications

Citations

558

H-Index

Active since

1995

Affiliations

University of Massachusetts Chan Medical School(Current)

Worcester Polytechnic Institute

Harvard University

Nicholas McHugh is an author at University of Massachusetts Chan Medical School specializing in rna interference, molecular biology, and small interfering rna (sirna) chemistry.

ORCID

Publications per year

1995–2025

Publications

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis et al. · Nucleic Acids Research · 2020 · 76 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh et al. · Molecular Therapy · 2020 · 76 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo et al. · Molecular Therapy — Nucleic Acids · 2022 · 55 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Qi Tang, Hassan H. Fakih, Mohammad Zain UI Abideen et al. · Nature Communications · 2023 · 49 citations · Full text

Life Sciences, Dermatology, Immunology +17

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Vignesh Hariharan, Minwook Shin, Ching‐Wen Chang et al. · Proceedings of the National Academy of Sciences · 2023 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Medicine +17

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