Nicholas McHugh

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis et al. · Nucleic Acids Research · 2020 · 74 citations · Full text

Medicinal Chemistry, Phosphorothioate Content, Robust Sirna Delivery +13

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh et al. · Molecular Therapy · 2020 · 70 citations · Full text

Muscle Tissue, Engineering, Biomedical Research +19

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo et al. · Molecular Therapy — Nucleic Acids · 2022 · 51 citations · Full text

Chemical Optimization, Engineering, Efficient Silencing +7

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Vignesh Hariharan, Minwook Shin, Ching‐Wen Chang et al. · Proceedings of the National Academy of Sciences · 2023 · 46 citations · Full text

Lung Inflammation, Viral Pathogenesis, Immunology +19

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Batuhan Yenilmez, Nicole Wetoska, Mark Kelly et al. · Molecular Therapy · 2021 · 45 citations · Full text