Annabelle Biscans

Diverse lipid conjugates for functional extra-hepatic siRNA delivery <i>in vivo</i>

Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti et al. · Nucleic Acids Research · 2018 · 197 citations · Full text

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Maire F. Osborn, Andrew H. Coles, Annabelle Biscans et al. · Nucleic Acids Research · 2018 · 131 citations · Full text

Sirna Internalization, Proteinlipid Interaction, Lipid-conjugated Sirnas +16

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

Reka A. Haraszti, Rachael Miller, Marie-Cécile Didiot et al. · Molecular Therapy · 2018 · 98 citations · Full text

Lipid Preparation, Extracellular Vesicles, Nanomedicine +14

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

Bruno M.D.C. Godinho, Nils Henninger, James Bouley et al. · Molecular Therapy · 2018 · 80 citations · Full text

Cell-based Drug Delivery, Nanomedicine, Drug Targeting +12

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis et al. · Nucleic Acids Research · 2020 · 74 citations · Full text

Medicinal Chemistry, Phosphorothioate Content, Robust Sirna Delivery +13