Concepedia

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi,

Molecular Therapy — Nucleic Acids · 2022 · 51 citations · 62 references

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62

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

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Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Sharon E. Maynard, Jiang-Yong Min, Jaime R. Merchan et al. · Journal of Clinical Investigation · 2003 · 3.9K citations · Full text

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

Adam D. Judge, Vandana Sood, Janet R. Shaw et al. · Nature Biotechnology · 2005 · 1.2K citations

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Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

Christian B. Matranga, Yukihide Tomari, Chanseok Shin et al. · Cell · 2005 · 1.1K citations · Full text

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siRNA function in RNAi: A chemical modification analysis

Ya‐Lin Chiu, Tariq M. Rana · RNA · 2003 · 853 citations · Full text

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