Eric Haaksma

Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

Flavio Solca, G. Dahl, Andreas Zoephel et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 848 citations

Ligand efficiency as a guide in fragment hit selection and optimization

Sabine Schultes, Chris de Graaf, Eric Haaksma et al. · Drug Discovery Today Technologies · 2010 · 241 citations · Full text

GRID/CPCA:  A New Computational Tool To Design Selective Ligands

Mika A. Kastenholz, Manuel Pastor, Gabriele Cruciani et al. · Journal of Medicinal Chemistry · 2000 · 184 citations · Full text

Drug Target, Computational Chemistry, Chemistry +20

Serine and Threonine Residues Bend α-Helices in the χ1=g− Conformation

Juan Antonio Ballesteros‐Cánovas, Xavier Deupí, Mireia Olivella et al. · Biophysical Journal · 2000 · 182 citations · Full text

Protein Chemistry, Biochemistry, Protein Folding +9

Linking agonist binding to histamine H1 receptor activation

Aldo Jongejan, Martijn Bruysters, Juan Antonio Ballesteros‐Cánovas et al. · Nature Chemical Biology · 2005 · 93 citations · Full text

H1 Receptor Activation, Signal Transduction, Molecular Physiology +7