Bone-Targeted 2,6,9-Trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases

Yihan Wang, Chester A. Metcalf, William C. Shakespeare, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySclerostinBone-targeted 2,6,9-Trisubstituted PurinesBone Morphogenic ProteinMedicine +8

Structure-activity relationships of a novel class of Src SH2 inhibitors

John L. Buchanan, Chi B. Vu, Taylor Merry, +11

Bioorganic & Medicinal Chemistry Letters

Molecular DockingBiochemistryMedicineNatural SciencesRational Drug Design +6

Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8)

Shomir Ghosh, Amy Elder, Jianping Guo, +20

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryLigand Ccl1BiochemistryFunctional Selectivity +11

Normal and Abnormal Heme Biosynthesis. 1. Synthesis and Metabolism of Di- and Monocarboxylic Porphyrinogens Related to Coproporphyrinogen-III and Harderoporphyrinogen:  A Model for the Active Site of Coproporphyrinogen Oxidase

Timothy D. Lash, Ukti N. Mani, Martin A. Drinan, +3

The Journal of Organic Chemistry

Copro'gen OxidaseMolecular BiologyOrganic ChemistryChemistryRedox Biology +18

Bone-Targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues

Raji Sundaramoorthi, William C. Shakespeare, Terence P. Keenan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePyrazolopyrimidine AnaloguesAnti-cancer AgentPharmacology +3

Normal and Abnormal Heme Biosynthesis. 2.¹ Synthesis and Metabolism of Type-III Pentacarboxylic Porphyrinogens:  Further Experimental Evidence for the Enzymic Clockwise Decarboxylation of Uroporphyrinogen-III

Timothy D. Lash, Ukti N. Mani, Elizabeth A. Lyons, +2

The Journal of Organic Chemistry

Normal and Abnormal Heme Biosynthesis. 3.¹ Synthesis and Metabolism of Tripropionate Analogues of Coproporphyrinogen-III:  Novel Probes for the Active Site of Coproporphyrinogen Oxidase

Timothy D. Lash, Troii Hall, Ukti N. Mani, +1

The Journal of Organic Chemistry

EngineeringCopro'gen OxidaseMolecular BiologyOrganic ChemistryChemistry +15

Normal and Abnormal Heme Biosynthesis. 6. Synthesis and Metabolism of a Series of Monovinylporphyrinogens Related to Harderoporphyrinogen. Further Insights into the Oxidative Decarboxylation of Porphyrinogen Substrates by Coproporphyrinogen Oxidase

Timothy D. Lash, Ukti N. Mani, Anna-Sigrid Keck, +1

The Journal of Organic Chemistry

Bioorganic ChemistryMolecular BiologyOrganic ChemistryDeoxygenationEnzymatic Modification +20

Synthetic substrates for coproporophyrinogen oxidase: mesoporphyrinogen-VI revisited

Timothy D. Lash, Martin A. Drinan, Chun Zhen, +2

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesBiocatalysisSynthetic SubstratesCatalysis +2