Issei Nitta

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.

Masanori Baba, Erik De Clercq, H. TANAKA et al. · Proceedings of the National Academy of Sciences · 1991 · 175 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

Hiromichi Tanaka, Hideaki Takashima, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1992 · 166 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogs: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity

Hiromichi Tanaka, Hideaki Takashima, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1992 · 139 citations

Medicine, Chemistry, Pharmacology +15

A new class of HIV-1 specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Hiromichi Tanaka, Masanori Baba, Hiroyuki Hayakawa et al. · Journal of Medicinal Chemistry · 1991 · 139 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

H. TANAKA, Masanori Baba, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1991 · 77 citations

Medicine, Chemistry, Pharmacology +10