Charlemagne S. Gallardo

Discovery and Structure−Activity Relationship of (1<i>R</i>)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1<i>H</i>-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT_2C Receptor Agonist for the Treatment of Obesity

Brian M. Smith, Jeffrey M. Smith, James H. Tsai et al. · Journal of Medicinal Chemistry · 2007 · 200 citations · Full text

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Brian M. Smith, Jeffrey M. Smith, James H. Tsai et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 85 citations · Full text

Obesity, New Benzazepines, Functional Selectivity +6

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

Graeme Semple, Vincent J. Santora, Jeffrey M. Smith et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations · Full text

Histamine H3 Receptor, Molecular Pharmacology, Medicinal Chemistry +11

Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H₃ Receptor Inverse Agonist Activity

Jonathan A. Covel, Vincent J. Santora, Jeffrey M. Smith et al. · Journal of Medicinal Chemistry · 2009 · 16 citations · Full text