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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

Graeme Semple, Vincent J. Santora, Jeffrey M. Smith, Jonathan A. Covel, Rena Hayashi, Charlemagne S. Gallardo, Jason B. Ibarra, Jeffrey A. Schultz, Douglas M. Park, Scott A. Estrada,

Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations · 5 references

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References

5

Histamine and its receptors

Mike Parsons, C. Robin Ganellin · British Journal of Pharmacology · 2006 · 558 citations · Full text

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Histamine H3 receptor-mediated modulation of water consumption in the rat

Jane Clapham, Gavin J. Kilpatrick · European Journal of Pharmacology · 1993 · 62 citations

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A new family of H3 receptor antagonists based on the natural product Conessine

Vincent J. Santora, Jonathan A. Covel, Rena Hayashi et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 32 citations · Full text

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Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H<sub>3</sub> Receptor Inverse Agonist Activity

Jonathan A. Covel, Vincent J. Santora, Jeffrey M. Smith et al. · Journal of Medicinal Chemistry · 2009 · 16 citations · Full text

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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series

Diana L. Nersesian, Lawrence A. Black, Thomas R. Miller et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 15 citations · Full text

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