Kantharaj Ethirajulu

MetaSite:  Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Gabriele Cruciani, Emanuele Carosati, Benoît De Boeck et al. · Journal of Medicinal Chemistry · 2005 · 491 citations

Medicine, Medicinal Chemistry, Pharmacology +17

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

Stefan Hart, K C Goh, Veronica Novotny‐Diermayr et al. · Leukemia · 2011 · 199 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma

Anthony D. William, Angeline C.-H. Lee, Stéphanie Blanchard et al. · Journal of Medicinal Chemistry · 2011 · 198 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Phase I Study of a Novel Oral Janus Kinase 2 Inhibitor, SB1518, in Patients With Relapsed Lymphoma: Evidence of Clinical and Biologic Activity in Multiple Lymphoma Subtypes

Anas Younes, Jorge Romaguera, Michelle A. Fanale et al. · Journal of Clinical Oncology · 2012 · 139 citations

Medicine, Oncology, Pharmacology +13

SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

Veronica Novotny‐Diermayr, Kanda Sangthongpitag, Chang Hu et al. · Molecular Cancer Therapeutics · 2010 · 132 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12