New Synthetic Technology for Efficient Construction of α-Hydroxy-β-amino Amides via the Passerini Reaction¹

J. Edward Semple, Timothy D. Owens, Khanh Hung Nguyen, +1

Organic Letters

-Alpha-ketoamide Protease InhibitorsOrganic ChemistryChemistryPharmaceutical Chemistryα-Hydroxy-β-amino Amides +14

Discovery of SCH446211 (SCH6):  A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

Stéphane Bogen, Ashok Arasappan, Frank Bennett, +26

Journal of Medicinal Chemistry

Viral ReplicationImmunologyMolecular BiologyTranscriptional RegulationHcv Genome +14

Highly Selective Mechanism-Based Thrombin Inhibitors:  Structures of Thrombin and Trypsin Inhibited with Rigid Peptidyl Aldehydes

Rahul Krishnan, E. Zhang, Kjell Erik Julius Håkansson, +6

Biochemistry

Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action

Odile E. Levy, Carolyn M. Jodka, Shijun Steven Ren, +8

PLoS ONE

Improved Glucose Control and Reduced Body Weight in Rodents with Dual Mechanism of Action Peptide Hybrids

James L. Trevaskis, Christine M. Mack, Chengzao Sun, +12

PLoS ONE

Potent and Selective Thrombin Inhibitors Incorporating the Constrained Arginine Mimic <scp>l</scp>-3-Piperidyl(<i>N</i>-guanidino)alanine at P₁

Odile E. Levy, J. Edward Semple, Michael Lim, +8

Journal of Medicinal Chemistry

Altmetric Attention ScoreScience Park RoadPharmacotherapyChemical BiologyPharmaceutical Chemistry +15

A novel long‐acting glucose‐dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents

Krystyna Tatarkiewicz, D. M. Hargrove, Carolyn M. Jodka, +10

Diabetes Obesity and Metabolism

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:mrow><mml:msubsup><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> moiety with improved potency

Ashok Arasappan, F. George Njoroge, Tze‐Ming Chan, +33

Bioorganic & Medicinal Chemistry Letters

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic p1-ketoamide moieties

J. Edward Semple, Odile E. Levy, Nathaniel K. Minami, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural Sciences +7

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa

Susan Y. Tamura, Odile E. Levy, Theresa H. Uong, +8

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesPeptoidRational Drug Design +7