Anne Ast

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex

Annika Scior, Alexander Buntru, Kristin Arnsburg et al. · The EMBO Journal · 2017 · 133 citations · Full text

Biochemistry, Htt Fibrils, Protein Folding +4

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease

Anne Ast, Alexander Buntru, Franziska Schindler et al. · Molecular Cell · 2018 · 75 citations · Full text

Neurodegenerative Diseases, Developmental Biology, Huntington ’ +9

Self-assembly of Mutant Huntingtin Exon-1 Fragments into Large Complex Fibrillar Structures Involves Nucleated Branching

Anne S. Wagner, Antonio Z. Politi, Anne Ast et al. · Journal of Molecular Biology · 2018 · 59 citations · Full text

Protein Assembly, Molecular Biology, Single Molecule Biophysics +18

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches

Edward J. Smith, Kirupa Sathasivam, Christian Landles et al. · Brain Communications · 2022 · 35 citations · Full text

Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology

Marie Rieux, Melanie Alpaugh, Giacomo Sciacca et al. · Molecular Psychiatry · 2020 · 30 citations · Full text