Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

Claus-Werner Franzke, Cristina Cobzaru, Antigoni Triantafyllopoulou, +7

The Journal of Experimental Medicine

ImmunologyImmune RegulationSkin ArchitectureDermal StructureInnate Immunity +25

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

Lars Michel, Iris Helfrich, Ulrike B. Hendgen‐Cotta, +19

European Heart Journal

Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression

Venugopal R. Mittapalli, Josef Madl, Stefanie Löffek, +5

Cancer Research

EngineeringPathologyDermal StructureDermatologyTumor Biology +19

Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling

Stefanie Löffek, Tiina Hurskainen, J. Jackow, +5

PLoS ONE

Cell AdhesionCytoskeletonCellular PhysiologyTumor BiologyAdhesion Protein +15

High Invasive Melanoma Cells Induce Matrix Metalloproteinase-1 Synthesis in Fibroblasts by Interleukin-1α and Basic Fibroblast Growth Factor-Mediated Mechanisms

Stefanie Löffek, Paola Zigrino, Peter Angel, +3

Journal of Investigative Dermatology

InflammationMedicineMelanomaImmunologyCell-matrix Interaction +6

Role of ADAM-9 Disintegrin-Cysteine-rich Domains in Human Keratinocyte Migration

Paola Zigrino, Julia Steiger, Jay W. Fox, +4

Journal of Biological Chemistry

Cell AdhesionImmunologyDermatologyAdam-9 BelongsMatrix Biology +15

Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer

Jyri Moilanen, Nina Kokkonen, Stefanie Löffek, +10

Human Pathology

MedicinePathologyColorectal CancerCell-matrix InteractionCancer Biology +5

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

Stefanie Löffek, Stefan Wöll, Jörg Höhfeld, +4

Human Mutation

Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling

J. Jackow, Stefanie Löffek, Alexander Nyström, +2

Journal of Investigative Dermatology

Skin DevelopmentDevelopmental BiologyMedicineKeratinocyte MigrationCutaneous Biology +9

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells

Jyri Moilanen, Stefanie Löffek, Nina Kokkonen, +11

Scientific Reports

Collagen XviiMedicineCell AdhesionPathologyCancer Cell Biology +13