Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

Margherita Brindisi, Simone Brogi, Nicola Relitti, +10

Scientific Reports

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors

Giuseppe Campiani, Caterina Cavella, J.D. Osko, +34

Journal of Medicinal Chemistry

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation

Nicola Relitti, A. Prasanth Saraswati, Giulia Chemi, +14

European Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +8

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, +28

ACS Medicinal Chemistry Letters

Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of <i>in Vitro</i> Splicing Inhibition

Arun K. Ghosh, Anne M. Veitschegger, Shenyou Nie, +3

The Journal of Organic Chemistry

Screening and Phenotypical Characterization of <i>Schistosoma mansoni</i> Histone Deacetylase 8 (<i>Sm</i>HDAC8) Inhibitors as Multistage Antischistosomal Agents

Fulvio Saccoccia, Margherita Brindisi, Roberto Gimmelli, +14

ACS Infectious Diseases

Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability

Stefano Federico, Tuhina Khan, Anna Fontana, +30

European Journal of Medicinal Chemistry

Dual Hhdac6/hdac8 InhibitorsBiochemistryMedicineNatural SciencesAzetidin-2-one-based Small Molecules +9

Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

Arun K. Ghosh, Guddeti Chandrashekar Reddy, Satish Kovela, +4

Organic Letters

Combinatorial ChemistryCyclopropane DerivativeMolecular BiologyOrganic ChemistryChemical Biology +15

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents

Alessandro Grillo, Filomena Fezza, Giulia Chemi, +21

ACS Chemical Neuroscience

Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies

Stefania Butini, Emanuele Gabellieri, Margherita Brindisi, +10

Bioorganic & Medicinal Chemistry Letters

Novel PeptidomimeticsBiochemistryMedicineNatural SciencesPeptoid +8