J.D. Osko

Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

Nicholas J. Porter, J.D. Osko, Daniela Diedrich et al. · Journal of Medicinal Chemistry · 2018 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of the First-in-Class Dual Histone Deacetylase–Proteasome Inhibitor

Sanil Bhatia, Viktoria Krieger, M. Groll et al. · Journal of Medicinal Chemistry · 2018 · 77 citations · Full text

Medicine, Oncology, Pharmacology +13

Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6

J.D. Osko, David W. Christianson · Biochemistry · 2019 · 73 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Multicomponent Synthesis and Binding Mode of Imidazo[1,2-<i>a</i>]pyridine-Capped Selective HDAC6 Inhibitors

Marcel K. W. Mackwitz, Alexandra Hamacher, J.D. Osko et al. · Organic Letters · 2018 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors

Giuseppe Campiani, Caterina Cavella, J.D. Osko et al. · Journal of Medicinal Chemistry · 2021 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15