Xavier M. Anguela

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

Lindsey A. George, Spencer K. Sullivan, Adam Giermasz et al. · New England Journal of Medicine · 2017 · 736 citations · Full text

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Hojun Li, Virginia Haurigot, Yannick Doyon et al. · Nature · 2011 · 540 citations

Vivo Genome, Knockout Mouse, Engineering +12

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

Federico Mingozzi, Xavier M. Anguela, Giulia Pavani et al. · Science Translational Medicine · 2013 · 335 citations · Full text

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Rajiv P. Sharma, Xavier M. Anguela, Yannick Doyon et al. · Blood · 2015 · 295 citations · Full text

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

Christian Leborgne, Elena Barbon, J M Alexander et al. · Nature Medicine · 2020 · 295 citations · Full text

Vivo Gene Therapy, Autoimmune Disease, Igg-cleaving Endopeptidase Enables +8