Timothy A. Vortherms

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Matthew S. Goldberg, Antonio Pisani, Marián Haburčák et al. · Neuron · 2005 · 542 citations · Full text

Genetics, Parkinson Disease, Neurology +6

Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors

Feng Yan, Philip D. Mosier, Richard B. Westkaemper et al. · Biochemistry · 2005 · 91 citations · Full text

Salvinorin A, Drug Target, Free Thiol +16

Discovery of 4-[(2 <i>R</i> ,4 <i>R</i> )-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2 <i>H</i> -chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis

Xueqing Wang, Bo Liu, Xenia B. Searle et al. · Journal of Medicinal Chemistry · 2017 · 76 citations

Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H₄Receptor Ligands

Robert J. Altenbach, Ronald M. Adair, Brian M. Bettencourt et al. · Journal of Medicinal Chemistry · 2008 · 58 citations · Full text

<i>cis</i>-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-<i>h</i>]quinazolin-2-amine (A-987306), A New Histamine H₄R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia

Huaqing Liu, Robert J. Altenbach, Tracy L. Carr et al. · Journal of Medicinal Chemistry · 2008 · 48 citations · Full text

Pain Disorders, Pain Medicine, Immunology +21