Xenia B. Searle

Discovery of 4-[(2 <i>R</i> ,4 <i>R</i> )-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2 <i>H</i> -chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis

Xueqing Wang, Bo Liu, Xenia B. Searle et al. · Journal of Medicinal Chemistry · 2017 · 76 citations

Structure−Activity Studies and Analgesic Efficacy of<i>N-</i>(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors

William H. Bunnelle, Jerome F. Daanen, Keith B. Ryther et al. · Journal of Medicinal Chemistry · 2007 · 57 citations · Full text

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2

George S. Sheppard, Jieyi Wang, Megumi Kawai et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 40 citations · Full text

Medicinal Chemistry, Methionine Aminopeptidase-2, Biochemistry +7

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis

Marc J. C. Scanio, Xenia B. Searle, Bo Liu et al. · ACS Medicinal Chemistry Letters · 2019 · 36 citations · Full text

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222

Ashvani K. Singh, Yihong Fan, Corina Balut et al. · Journal of Pharmacology and Experimental Therapeutics · 2019 · 29 citations · Full text