Helen Sanger

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Siobhan Dennis, Francesca Pasqui, Ellen M. Colvin et al. · Cerebral Cortex · 2015 · 141 citations · Full text

Synaptic Transmission, Neurotransmitter, Neurotransmission +17

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Sophie J. Bradley, Julie-Myrtille Bourgognon, Helen Sanger et al. · Journal of Clinical Investigation · 2016 · 78 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Cholinergic Transmission +13

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 59 citations

Pharmacological Characterization, Pharmacotherapy, Experimental Pharmacology +18

Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR

Helen Sanger, Lydia Hanna, Ellen M. Colvin et al. · Neuropharmacology · 2012 · 30 citations

Neurophysiology, Neuroanatomy, Medicine +11

Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

Sophie J. Bradley, Colin Molloy, Christoffer Bundgaard et al. · Molecular Pharmacology · 2018 · 29 citations · Full text