New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial

Faustino Torrico, Joaquím Gascón, Fabiana Barreira, +33

The Lancet Infectious Diseases

Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities

Erica L. Bradshaw, Mary E. Spilker, Richard Zang, +11

CPT Pharmacometrics & Systems Pharmacology

Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase

Dana Ferraris, Bridget Duvall, Greg Delahanty, +10

Journal of Medicinal Chemistry

Cda SubstrateMedicinal ChemistryCda-mediated MetabolismInhibitory ActivityCytidine Deaminase +13

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, +21

The AAPS Journal

Translational MedicinePharmacokinetic ModelingPharmacologyIq Consortium SurveyCurrent Landscape +7

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Hugo Geerts, John P. Wikswo, Piet H. van der Graaf, +8

CPT Pharmacometrics & Systems Pharmacology

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic <scp>Physiologically‐Based Pharmacokinetic</scp> Model

Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, +11

CPT Pharmacometrics & Systems Pharmacology

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects

Yanke Yu, Veronika Logovinsky, Edgar Schuck, +5

The Journal of Clinical Pharmacology

Molecular PharmacologyClinical DisordersPd ResponseAlzheimer's DiseaseAllergy +12

Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of a Once-Daily Treatment Using Ciprofloxacin in an Extended-Release Dosage Form*

Edgar Schuck, A. Dalhoff, Hartmut Derendorf

Infection

MedicineClinical PharmacologyPharmacotherapyAntimicrobial PharmacokineticsPharmacology +2

Perampanel and pregnancy

Blanca Vázquez, Torbjörn Tomson, Cindy Dobrinsky, +2

Epilepsia

Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers

Edgar Schuck, Maria B. Grant, Hartmut Derendorf

The Journal of Clinical Pharmacology

MechanobiologyEngineeringPharmacokinetic ModelingTissue PenetrationHealthy Volunteers +10