Laura J. Signor

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

Valentin K. Gribkoff, John E. Starrett, Steven I. Dworetzky et al. · Nature Medicine · 2001 · 311 citations

Life Sciences, Neurology, Neuroscience +16

Luminescence Thermometry Beyond the Biological Realm

Benjamin Harrington, Ziyang Ye, Laura J. Signor et al. · ACS Nanoscience Au · 2023 · 70 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +17

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery

Prasad V. Chaturvedula, Stephen E. Mercer, Sokhom S. Pin et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of (<i>R</i>)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-<i>N</i>-(3-(7-methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

Andrew P. Degnan, Prasad V. Chaturvedula, Charles M. Conway et al. · Journal of Medicinal Chemistry · 2008 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1 H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties

Svetlana Tertyshnikova, Ronald J. Knox, Mary Jane Plym et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 57 citations

Natural Sciences, Pharmacology, Physiology +17