Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Daniel A. Michelson, Koji Hase, Tsuneyasu Kaisho, +2

Cell

Lymphocyte DevelopmentT-regulatory CellImmunologyRegulatory T CellsSelf-tolerance +7

Profound Treg perturbations correlate with COVID-19 severity

Silvia Galván-Peña, Juliette Léon, Kaitavjeet Chowdhary, +13

Proceedings of the National Academy of Sciences

Profound Treg perturbations correlate with COVID-19 severity

Silvia Galván-Peña, Juliette Léon, Kaitavjeet Chowdhary, +12

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Juliette Léon, Daniel A. Michelson, Judith Olejnik, +13

Proceedings of the National Academy of Sciences

InflammationLung InflammationInflammatory MalfunctionHumoral ResponseViral Pathogenesis +12

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Daniel A. Michelson, Chong Zuo, Michael P. Verzi, +2

The Journal of Experimental Medicine

Lymphocyte DevelopmentImmunologyImmune RegulationEpigeneticsTranscriptional Regulation +23

Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers

Kushagra Bansal, Daniel A. Michelson, Ricardo N. Ramírez, +4

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyEpigeneticsTranscriptional RegulationCohesin Subunits +14

Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting

Ravi K. Dinesh, Benjamin Barnhill, Anoj Ilanges, +7

European Journal of Immunology

GeneticsGenomic MechanismGene CharacterizationMolecular GeneticsShm Reporter Assays +21

A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue

Omar Yaghi, Bola S. Hanna, P. Kent Langston, +5

Nature Immunology

Cell TherapyImmunocyte RecruitmentImmunologyBlood CellStem Cell Research +4

Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements

Brooke D. Huisman, Daniel A. Michelson, Sara A. Rubin, +9

Immunity

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance

Daniel A. Michelson, Christophe Benoıst, Diane Mathis

Proceedings of the National Academy of Sciences