Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

Yu Zhu, John M. Herndon, Dorothy K. Sojka, +12

Immunity

Pancreatic CancerPromote Tumor ProgressionTissue-resident MacrophagesTumor ImmunityPathology +6

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

Samarth Hegde, Varintra E. Krisnawan, Brett H. Herzog, +16

Cancer Cell

Cancer ImmunosurveillancePancreatic CancerImmunologyTumor ImmunityPathology +8

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Daniel Cui Zhou, Reyka G. Jayasinghe, Siqi Chen, +63

Nature Genetics

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

Roheena Z. Panni, John M. Herndon, Chong Zuo, +12

Science Translational Medicine

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade

Varintra E. Lander, Jad I. Belle, Natalie L. Kingston, +17

Cancer Discovery

Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Xiuting Liu, Graham D. Hogg, Chong Zuo, +17

Cancer Cell

Context-dependent ActivationCancer ImmunosurveillanceAllergyCd11b AgonistsSting-interferon Signaling +9

Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

John Baer, Chong Zuo, Liang‐I Kang, +16

Nature Immunology

InflammationChronic Inflammatory DiseasesFibrosisInflammatory DiseaseDivergent Roles +9

Potassium channel selectivity filter dynamics revealed by single-molecule FRET

Shizhen Wang, Sun‐Joo Lee, Grigory Maksaev, +3

Nature Chemical Biology

Single-molecule FretSingle MoleculeSingle Molecule BiophysicsBiophysics

The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation

Marcel O. Schmidt, Khalid A. Garman, Yong Gu Lee, +9

Journal of Investigative Dermatology

FibrosisCancer GrowthPathologyFibroblast Growth FactorDermatology +7

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

Chong Zuo, John Baer, Brett L. Knolhoff, +18

The Journal of Experimental Medicine

Tumor-associated MacrophagesTam ProliferationImmunologyPathologyImmunologic Mechanism +17